Pyruvate oxidation
Pyruvate Oxidation
Pyruvate oxidation is the second stage of cellular respiration. At this point two pyruvate molecules have been created and transported from the cytosol and through the mitochondrial membrane and into the matrix. The pyruvate is made of an acetyl group and a low-energy carboxyl group. Frist what happen is a decarboxylation reaction that removes carbon dioxide from the carboxyl group. Then you have the acetyl group left which is oxidized by NAD+. The NAD+ gains hydrogens and becomes NADH this causes the pyruvate to be oxidized. Finally to create the product you want the coenzyme A (CoA) comes in and attaches to what left of the acetyl group and creates acetyl-CoA. Remember this happens twice because you had two pyruvate molecules that have now become two molecules of acetyl-CoA.
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Picture received from: https://www.khanacademy.org/science/biology/cellular-respiration-and-fermentation/pyruvate-oxidation-and-the-citric-acid-cycle/a/pyruvate-oxidation
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Teaching resources
Below are a few teaching resources that one can use to help reinforce pyruvate oxidation for students. Since pyruvate oxidation is a short stage compared to the other stages so most activities and worksheet combine both pyruvate oxidation and Kreb's cycle together.
STUdent WOrksheet
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Received from: http://www.rosedaletube.com/zfiles/science/SBI4U/Unit%202/SBI4U%202-2%20Glycolysis%20Updated%20-%20Storyline%20output/story_content/external_files/SBI4u%202-2%20Glycolysis%20Worksheet.pdf
The Pantomime
This activity is a hands on way for students to learn about pyruvate oxidation and how it connects to Krebs cycle and what happens in Krebs cycle. Since it connects them together you will find the details of this activity under Krebs cycle.
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